|Contributions||University of Manchester. Faculty of Medicine.|
|The Physical Object|
|Number of Pages||175|
Integrin signaling in malignant melanoma. Cancer Metastasis Rev. ; – Lee JT, Herlyn M. Microenvironmental influences in melanoma progression. J Cell Biochem. ; – Massi D, Naldini A, Ardinghi C, et al. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma. Hum by: The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved in these processes. Thus, we have attempted to utilize this approach through the analysis of a series of primary, non-metastatic cutaneous tumors and metastatic melanoma by: Proteinase activated receptors (PAR ) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. To evaluate the significance of expression and co-expression of PAR in cancer we performed a survey on published data. A Pubmed literature search on “PAR, thrombin, cancer” was Cited by: Expression and the role of cathepsin H in human glioma progression and invasion. Cancer Lett. Jun 24; (1)– Sukoh N, Abe S, Ogura S, Isobe H, Takekawa H, Inoue K, Kawakami Y. Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer. Cancer. Jul 1; 74 (1)–
(). Denhardt DT: Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells. Cancer Res (). E: A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells. Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis. Elevation of the cathepsins of the cysteine protease family correlates with increased invasion of tumor cells. Cysteine proteases such as cathepsins B, H and L type participate in tumor cell invasion as extracellular proteases, yet are enzymes. Invasion of basement membranes is a key step in systemic spread of tumour cells. To analyze genetic mechanisms involved in this process, we have selected strongly and weakly invasive sublines with stable phenotypes from a primary human melanoma cell line by repeated passage through a reconstituted basement membrane in vitro. The sublines differed approximately 5‐fold in their invasive potential. The Basic Biology of Malignant Melanoma: Molecular Mechanisms of Disease Progression and Comparative Aspects Shola S. Sulaimon and Barbara E. Kitchell Malignant melanoma (MM) is a life-threatening disease characterized by a highly aggressive biologic behavior in both humans and dogs.
In the context of inflammatory disease, Y-box binding protein 1 (YB-1) is actively secreted and the extracellular protein promotes cell proliferation and migration. In malignant melanoma, intracellular YB-1 expression increases during melanoma progression and represents an unfavourable prognostic marker. In a skin reconstruction model, ectopic E-cadherin expression inhibits invasion of melanoma cells into dermis by down-regulating invasion-related adhesion receptors, MelCAM/MUC18 and beta3. ous melanoma, like alterations of tumor cell proliferation and cell cycle regulation, cell adhesion proteins, and tumor associated angiogenesis . Although necrosis and tumor cell apoptosis are strongly related to the behav-iour of malignant tumors, these characteristics have not been well studied in human melanomas. We therefore. Introduction. Malignant melanoma is a highly aggressive disease for which successful treatment modalities have not been established. A number of genetic alterations including loss of tumor suppressor proteins encoded by the INK4a/ARF gene locus, or oncogenic BRAF mutations, occur early during melanomagenesis,,.However, the key event in the progression of melanoma toward a malignant, .